POMC and myalgic encephalomeyelitis/chronic fatigue syndrome: If confirmed prospectively, depressed ACTH and possibly glucose might offer an objective way to confirm the diagnosis of CFS at 6 months following IM, while persistence of increased T4 and decreased morning salivary cortisol coupled with decreased estradiol at 12 months and increased neutrophil counts at 24 months might provide objective evidence for the persistence of CFS.