In comparison with T cells primed by GM-CSF and IL-4 or PBS treated CLL cells, GIFT4-CLL cell-primed T cells produced substantial amount of cytotoxic IFN-γ, MIP1A (CCL3), as well as FAS ligand, TRAIL, TNF-α, MIG (CXCL9), and IP-10 (Fig. 6a) relative to control. The gene discussed is TNFSF10; the disease is B-cell chronic lymphocytic leukemia.