After 24-h culture, the primary CLL cells were profiled by FACS with anti-human CD19 antibody and Annexin V. Apoptotic assay showed that GIFT4-CLL cell-primed T cells significantly induced apoptosis of the primary CLL cells in comparison with control T cells (Fig. 7a, b), with 30.8 % of average apoptotic death induced by GIFT4-CLL cell-primed T cells (Fig. 7d). This evidence concerns the gene ANXA5 and B-cell chronic lymphocytic leukemia.