To test whether human GIFT4-CLL cells could promote the expansion of T cells from subjects with CLL in vivo, we adoptively transferred CLL-containing PBMC into NOD-scid IL2Rγnull (NSG) immune deficient mice, and treated the mice with GIFT4, GM-CSF and IL-4 or PBS. The gene discussed is IL4; the disease is B-cell chronic lymphocytic leukemia.