Identification of a homozygous mutation causing recessive neonatal diabetes, however, would clearly define the extent of the reduction in channel ATP sensitivity that is sufficient to cause neonatal diabetes and also help determine whether the small decrease in ATP sensitivity caused by the Kir6.2-E23K variant is enough to account for the increased type 2 diabetes risk. The gene discussed is KCNJ11; the disease is type 2 diabetes mellitus.