Ang II–induced activation of p38 MAPK is also associated with the development and progression of fibrosis, commonly observed in aging and hypertension.72, 73, 74 It has been suggested that Ang II induces activity of MMPs and TIMPs and upregulation of CTGF during aging.75, 76, 77, 78, 79, 80. The gene discussed is AGT; the disease is hypertensive disorder.