Remyelination has received considerable attention as a potential therapeutic strategy in multiple sclerosis, with several drugs in pre-clinical development or clinical trials, including anti-Lingo-1 antibody, antagonists of M1 and/or M3 muscarinic receptors (benztropine), antihistamine and anticholinergic drugs (clemastine), and mitochondrial pore modulators (TRO19622) [8, 20, 50]. This evidence concerns the gene CHRM3 and multiple sclerosis.