Mutations in patients with USH2D, who have milder and more variable hearing abnormalities, have been localized to exons 1 and 2 and intron 2 of DFNB31 (Audo et al., 2011, Besnard et al., 2012, Ebermann et al., 2007), which affect PDZ1 and PDZ2 of WHRN-L, but likely have no impact on the expression of WHRN-S. The gene discussed is WHRN; the disease is Usher syndrome type 2D.