In total cases, the significant factors including Child-Pugh Classification score 5 (p = 0.015), absent AE (p < 0.001), lower ALT (p = 0.036), lower AFP (p < 0.001), tumor size ≤ 5 cm (p = 0.046), tumor numbers ≤ 3 (p = 0.001), sorafenib duration ≤ 1 cycle (p < 0.001), and absent TACE (p = 0.031) affected patient’s survival. The gene discussed is AFP; the disease is neoplasm.