CXCL2 and hepatocellular carcinoma: As showed in Fig. 8a, compared with the normal control, conditioned medium from the co-culture system could dramatically increased the migration and invasion ability of HCC cells (697.67 ± 64.08 vs. 214.67 ± 12.74 and 75.67 ± 6.43 vs. 16.00 ± 4.00, respectively); However, when co-culture CM was treated with different does of anti-CXCL2 antibody, both of these effects were significantly weaken, no matter in 1 ug/mL or 10 ug/mL concentration, along with a dose-dependent reduction effect.