The abnormal expression of CXCL2 has been observed in tissues of colon cancer patients40, plasma of primary chronic lymphocytic leukemia patients, culture supernatants of primary chronic lymphocytic leukemia peripheral blood mononuclear cells41, and conditioned medium of prostate stromal cells following stimulation by immortalized prostate epithelial cells42. The gene discussed is CXCL2; the disease is malignant colon neoplasm.