APOE4 was a widely validated genetic risk but merely accounted for a limited percentage of LOAD risk, several genome-wide association studies (GWAS) and meta-analyses had revealed a series of new risk loci associated with the late-onset type of AD (LOAD; >65 years of age)9, 10, 11, 12, to some extent filling up the vacant area of its genetic etiology. The gene discussed is APOE; the disease is Alzheimer disease.