Future studies should help identifying determinants of LIMK1 and LIMK2 association with distinct cellular compartments, i.e. endosomes and plasma membrane possibly underlying some differential functions of the two related LIMK-family members and spatio-temporal regulation of MT1-MMP phosphorylation by LIMK1 and/or LIMK2 during tumor cell invasion. The gene discussed is LIMK1; the disease is neoplasm.