A protective association for DPB1*02:01 and DPB1*04:01 was detected with SSc with ATA (P = 2.06X10-8, Pc = 3.50X10-7, OR 0.24, 95%CI 0.14–0.42; P = 4.18X10-5, Pc = 0.0007, OR 0.04, 95%CI 0.00–0.62, respectively, S4 Table). Here, HLA-DPB1 is linked to systemic sclerosis.