AFP and neoplasm: Although this study was designed with a prognostic intent, the variables included in the ITA.LI.CA prognostic system have an established impact on treatment decision, as recently underlined by the position paper of the Italian Association for the Study of the Liver [28]: (a) size and number of nodules and vascular invasion (used to determine tumor stage 0, A, B1, B2, B3, C), (b) the liver function and patient-related variables CPS and ECOG PST (the ITA.LI.CA functional score), and (c) AFP level.