POU5F1 and type 2 diabetes mellitus: The association of the six-loci GRS with type 2 diabetes is therefore probably not stronger than that of rs3130501 in POU5F1 (p = 0.017) or rs4275659 near MPHOSPH9 (p = 0.012) alone, suggesting that although the POU5F1 and MPHOSPH9 loci may individually have some effect on susceptibility to type 2 diabetes, the overall effect of the six SNP loci is not major in the Japanese.