Less frequently DH DLBCL may have translocations involving c-MYC and BCL6, and more rarely what studies in past decade called “triple-hit” lymphoma when the c-MYC, BCL2, and BCL6 rearrangements present concordantly; most of the studies analyzed data from patients with THL indicate inferior survival when treated with the conventional treatment.15 This evidence concerns the gene MYC and diffuse large B-cell lymphoma.