MYC and diffuse large B-cell lymphoma: The 3 most common chromosomal translocations in DLBCL involve the following oncogenes: (a) BCL2 (gene rearrangement at 18q21), found in more than 30% DLBCL, mainly in the GC molecular subtype, which when present as the only abnormality does not affect DLBCL survival outcome11; (b) BCL6 (gene rearrangement at 3q27) seen in about a third of patients with no prognostic value when present alone12; (c) and c-MYC (gene rearrangement at 8q24), seen in up to 15% of cases of DLBCL, which alone portends a worse prognosis following treatment with standard doxorubicin-based combination chemotherapy.13