AGER and diabetic kidney disease: Many studies have reported on the associations of the common RAGE polymorphisms such as G82S, −374T/A, −429T/C, 1704G/T, 2184A/G and 2250G/A with the development of diabetic nephropathy (Matsunaga-Irie et al., 2004; Prevost et al., 2005; Kanková et al., 2005; Lindholm et al., 2006).