AGER and kidney disorder: In addition to diabetic nephropathy, RAGE is also associated with the pathogenesis of non-diabetic renal diseases, for example, podocyte stress and glomerulosclerosis were elicited in doxorubicin-treated mice, but these features were decreased in the homozygous RAGE-null mice treated with doxorubicin (Guo et al., 2008).