ABCD1 and adrenoleukodystrophy: For further elucidation of the VLCFAs-triggered pathogenesis of X-ALD, astrocytes from wild-type control and a genetic X-ALD mouse model (Abcd1-knockout) were exposed to supraphysiological concentrations of VLCFAs (C22:0, C24:0 and C26:0) [67].