To serve the purpose, carcinoembryonic antigen (CEA) a glycoprotein present in tissue as well as in serum is most commonly used as traditional biomarker (diagnostic and prognostic) but CEA levels does not provide sufficient sensitivity and reliability for the early detection of CRC, therefore CEA like single gene based biomarkers clinical utility is questionable (4). This evidence concerns the gene CEACAM5 and colorectal carcinoma.