Studies show that APOC3 expression promotes the assembly and secretion of the bigger triglyceride-rich VLDL from hepatocytes through the mobilization of endoplasmic reticulum/Golgi microsomes triglyceride for VLDL assembly.45 This intracellular mechanism is manifest under conditions of insulin resistance or hypertriglyceridemia,21 though our results suggest it also operates under normal conditions. This evidence concerns the gene APOC3 and Insulin resistance.