APOC3 and hypertriglyceridemia: Studies show that APOC3 expression promotes the assembly and secretion of the bigger triglyceride-rich VLDL from hepatocytes through the mobilization of endoplasmic reticulum/Golgi microsomes triglyceride for VLDL assembly.45 This intracellular mechanism is manifest under conditions of insulin resistance or hypertriglyceridemia,21 though our results suggest it also operates under normal conditions.