Palmitate supplementation downregulated the majority of genes associated with the Wnt pathway (Fig. 2) and is in agreement with the idea presented by Du et al. (2010) concerning the inhibitory effect of maternal obesity on Wnt/beta-catenin signaling, leading to impairment of fetal myogenesis. This evidence concerns the gene CTNNB1 and obesity due to melanocortin 4 receptor deficiency.