SHBG and osteoporosis: Similar relationships between SHBG and free estradiol levels explain how serum SHBG levels contribute to abnormal estrogen exposures in lean women who have high SHBG levels and at risk for osteoporosis (Davidson et al. 1982, Devine et al. 2005) vs obese postmenopausal women who have low SHBG levels and are at high risk for endometrial cancer (Nisker et al. 1980).