By contrast, peroxisome proliferator-activated receptor gamma (PPARγ) appears to interact with a different NHR response element in the SHBG proximal promoter to repress transcription in hepatocytes cultured in vitro (Selva & Hammond 2009b), and this may explain the lower plasma SHBG levels in subjects with a hyperactive 12 Ala PPARγ variant (Mousavinasab et al. 2006) that has been linked with low risk for type 2 diabetes and myocardial infarction (Regieli et al. 2009). The gene discussed is SHBG; the disease is type 2 diabetes mellitus.