In SSc dermal fibroblasts it has been shown that 5′Aza′C reduced hypermethylation of the Wnt antagonist DKK1 and Secreted Frizzled RP1 (SFRP1) and thus enhanced their expression and this was associated with a blockade of pro-fibrotic Wnt signalling and in vivo 5′Aza′C ameliorated bleomycin induced fibrosis37. The gene discussed is DKK1; the disease is systemic sclerosis.