TET1 and systemic sclerosis: Figure 6C demonstrated no difference in TET1 levels suggesting this is not a factor influencing this. We further examined the expression of the methyltransferase enzyme Enhancer of Zeste Homolouge 2 (Ezh2) which is important for the transfer of methyl groups and this was reduced in the SSc fibroblasts but not statistically significant (Fig. 6D). There was also no significant difference in the methyltransferase ASH1 (Fig. 6D).