The correlation between EZH2 overexpression and nuclear grade was statistically significant, with 38.5 % (10/26), 57 % (49/86), and 69.3 % (79/114) of grade 1, 2, and 3 breast carcinomas having overexpression of EZH2, respectively (Chi-square, p < 0.05). Here, EZH2 is linked to breast carcinoma.