Compared to Eμ‐myc; Pot1b∆/∆ mice, Eμ‐myc; Pot1b∆/∆; p53R172P/+ mice exhibited dramatically reduced tumor‐free survival, with 12 of 12 mice succumbing to B‐cell lymphomas by 11 weeks of age (P < 0.001) (Figs 4E and S1B). This evidence concerns the gene MYC and B-cell non-Hodgkin lymphoma.