CASP3 and B-cell non-Hodgkin lymphoma: In support of this notion, transplantation of Pot1b∆/∆; p53−/− hematopoietic cells expressing Caspase 3C163A‐Myc into SCID mice resulted in significantly increased induction of B‐cell lymphomas, suggesting that p53‐independent apoptosis normally represses lymphomagenesis through the up‐regulation of Caspase 3 (Fig. 7C).