TP53 and cancer: Coupled with observations that deletion of Pot1a or Pot1b promotes end‐to‐end chromosome fusions that is tumor promoting in p53 mutant tumor prone mouse models (Wu et al., 2006; Hockemeyer et al., 2008; He et al., 2009; Wang et al., 2011), these results highlight the importance of POT1 in promoting genome stability to prevent the onset of cancer.