PAEP and Alzheimer disease: Similarly, we found significantly more mRNAs with altered expression in AD brains associated with TGFβ/GDF/BMP signaling than what would be expected by chance (p = 1.3×10−20, Kolmogorov-Smirnov test, Fig. 5c and Additional file 2), including CFC1 (Cripto, a co-factor of GDF3), and Activin-receptor subunits 2B and 1C (ACVR2B/ACVR1C, GDF3 receptors).