PAEP and Alzheimer disease: We used the Gene Ontology to identify a list of 114 genes linked to the TGFβ/GDF/BMP signaling pathway (Additional file 2) and queried two large AD data sets consisting of meta-data from 10 genome-wide association studies with a total of 8,309 AD cases and 7,366 cognitively normal elders [23] and AD brain transcriptome data from 181 AD and 125 controls [24] for significant SNPs or mRNA changes within the TGFβ/GDF/BMP pathway associated with AD.