GDF3 and Alzheimer disease: Given the important function adult hippocampal neurogenesis has in rodent behavior related to memory and learning, the recent discovery of significant hippocampal neurogenesis in the adult human brain even with advanced age [37], and previous implications of disturbed neurogenesis in AD [38, 39], changes in neurogenesis caused by abnormal GDF3 signaling might well have a role in the development or progression of AD.