It is important to stress that the results of Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER; testing liraglutide; ClinicalTrial.gov registration no. NCT01179048 [11]) and Exenatide Study of Cardiovascular Event Lowering Trial (EXSCEL; testing once-weekly exenatide; ClinicalTrial.gov registration no. NCT01144338) are eagerly awaited since they involve GLP-1 receptor agonists that have a longer duration of action than lixisenatide and have stronger glucose- and weight-lowering effects [12]. This evidence concerns the gene GLP1R and diabetes mellitus.