Meta-analyses were performed for immunological and virological outcomes (CD4 count, CD4 percentage, and viral load), cardiorespiratory outcomes (VO2max, HRmax, exercise time), strength outcomes (chest press, leg press, knee extension, knee flexion, upper and lower body strength), weight and body composition outcomes (body weight, body mass index, lean body mass, fat mass, percent body fat, leg muscle area, waist circumference, hip circumference, waist-to-hip ratio), and psychological outcomes (quality of life, depression-dejection symptoms). The gene discussed is CD4; the disease is depressive symptom measurement.