The French FPD/AML cohort consists of nine pedigrees (A to I) and two syndromic patients (J and K) with germline RUNX1 alterations identified in eight hospitals (La Timone and Paoli-Calmettes in Marseille; Nancy; La Pitié-Salpetrière, Saint-Louis and Trousseau in Paris; Reims, Rennes). Here, RUNX1 is linked to acute myeloid leukemia.