BRAF and metastatic melanoma: BRAF mutations are found in approximately 50% of metastatic melanomas [5] with V600E (c.1799T>A; p.Val600Glu), V600K (c.1798_1799delinsAA; p.Val600Lys), V600R (c.1798_1799delinsAG; p.Val600Arg) and V600M (c.1798G>A; p.Val600Met) in 79%, 12%, 5% and 4% frequencies respectively.