sCD200 release from CLL cells, like that of other well-characterized substrates of sheddases such as CD62L and CD44, could be further induced by external stimuli, including PMA and ionomycin [12, 35], through activation of intracellular 2nd messenger systems such as PKC or intracellular Ca2+ pathways [36]. The gene discussed is CD44; the disease is B-cell chronic lymphocytic leukemia.