Compared to the patients with p.262W (T allele of rs3184504) in LNK, those with p.262R(C allele of rs3184504) are at a higher risk to develop CML (P<0.01; OR = 17, 95%CI = 5.957–48.510). This evidence concerns the gene SH2B3 and chronic myelogenous leukemia, BCR-ABL1 positive.