RGS7 and obesity due to melanocortin 4 receptor deficiency: RGS7 is not listed among the candidate loci identified in genome-wide linkage or association studies of obesity-related phenotypes in humans; however, loci influencing these phenotypes or metabolic-related markers map close to RGS7. For instance, A genome-wide linkage scan in Caribbean Hispanics identified chromosome 1q43 at D1S547 (about 233 Kb telomeric to RGS7) as the strongest signal for body weight and as the second strongest signal for BMI [8].