However, in the present study, the clinical response to TNFI and IL-6RI, as determined by changes in the DAS28-CRP, tender and swollen joint counts, and VAS, was not influenced by the baseline serum levels of RF, anti-CCP IgG, and CRP, as well as by the genetic variants of 8 RA-related SNPs. This evidence concerns the gene CRP and rheumatoid arthritis.