The genotype and allele frequencies of the 8 polymorphisms (PADI4_94, PADI4_102, PADI4_104, PTPN22 R263Q, PTPN22 R620W, TNFA-863, TNFA -857, and IL-6–572) in relation to RA or response to bDMARD are shown in Table 5. This evidence concerns the gene IL6 and rheumatoid arthritis.