Most strikingly, of the 108 genes downregulated in AA CRC tumors, 14 were ribosomal proteins including 10 members of the large 60S subunit (RPL7A, RPL8, RPL13, RPL13A, RPL18, RPL28, RPL29, RPL36, RPLP0, and RPLP1), 3 members of the small 40S subunit (RPS2, RPS15, and RPS19), and 1 mitochondrial ribosomal protein (MRPL12) of the large 39S subunit (Table 5). The gene discussed is RPL8; the disease is colorectal carcinoma.