Here, we observed the aberrant hypermethylation of several genes that are implicated in anti-inflammatory mechanisms including NEL-Like 1 (NELL1) [49], Growth Differentiation Factor 1 (GDF1) [50], and Rho Guanine Nucleotide Exchange Factor (ARHGEF4) [51], and Integrin Alpha 4 (ITGA4) [52] in AA CRC but not CA CRC. Here, ARHGEF4 is linked to colorectal carcinoma.