The overmigration of neurons through the BM that was visible as a cobblestone lissencephaly in the C3GEmx1-KO resembles the phenotype of cortex-specific Ptk2 (encoding FAK) and Itgb1 (β1 integrin) knockouts [32, 33, 35, 36]. Here, PTK2 is linked to lissencephaly spectrum disorders.