TNF and Thrombocytopenia: Severity of CCHF correlates with increased viral load and dissemination, low anti-CCHFV antibody titers, severity of thrombocytopenia, increased clotting times, hemorrhage, high levels of pro-inflammatory cytokines (e.g., tumor necrosis factor α (TNFα), interleukin 6 (IL-6)), and elevated aspartate aminotransferase and alanine aminotransferase [6,7,8,9,10,11,12,13,14,15,16,17,18].