Expression of MDA5 and RIG-I has been shown to increase following infection by dsRNA viruses such as infectious pancreatic necrosis virus (IPNV) in Atlantic salmon [69] suggesting that these PRRs could play an important role in virus recognition by APCs and lead to their activation to enhance antigen uptake, processing and presention for activation of the adaptive immune system [70]. The gene discussed is RIGI; the disease is infection.