Another interesting study performed by Wang et al. [46] demonstrated that CUR may exert anti-amyloidogenic effects by inhibiting Phosphatidylinositol 3-Kinase (PI3K), phosphorylated protein kinase B (Akt) and mammalian target of rapamycin (mTOR) pathway (PI3K/Akt/mTOR pathway)-mediated formation of Aβ deposits in APP/PS1 AD mice [46]. This evidence concerns the gene PSEN1 and Alzheimer disease.