PSEN1 and neuroblastoma: In murine neuroblastoma cells Neuro2a overexpressing the mutant APPswe (N2a/APPswe), CUR treatment decreased the expression of presenilin-1 (PS1; γ-secretase) and beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1; β-secretase), proteases involved in the synthesis of Aβ plaques [44].