APP and neuroblastoma: In human neuroblastoma cells SH-SY5Y expressing the Swedish mutant of the Amyloid Precursor Protein (APPswe), CUR treatment significantly reduced Aβ production in a dose- and time-dependent manner and this Aβ reduction was mediated by serine 9 residue phosphorylation of Glycogen Synthase Kinase 3 (GSK3β), a key enzyme involved in the phosphorylation of the Amyloid Precursor Protein (APP) and Tau proteins [43].