APP and Cognitive impairment: In a recent work, Aso and coworkers [238] tested the therapeutic effects of the combination of Δ9-THC + CBD (0.75 mg/kg each) in a APP/PS1 transgenic mouse which mimics the most common features of the disease, including cognitive impairment and several pathological alterations, such as Aβ deposition, dystrophic neurites, synaptic failure, mitochondrial dysfunction, and oxidative stress damage.