Central or truncal obesity is linked to insulin resistance,47 and adipose tissue-specific amplification of glucocorticoid signaling induces all the characteristic features of MetS.48, 49, 50 We have now shown that the cold stress-induced augmentation of adipose tissue inflammation was associated with exacerbation of insulin resistance, consistent with previous findings.51 These observations suggest a possible role for GR signaling in macrophage recruitment in cardiac and adipose tissue as well as in insulin resistance. This evidence concerns the gene NR3C1 and metabolic syndrome.