Hypertension due to glucocorticoid excess is well recognized.14 Insulin resistance and inflammation may also result in altered vascular function and thereby trigger hypertension.29 In addition, the production of reactive oxygen species by NADPH oxidase has been implicated in glucocorticoid-induced hypertension.30, 31 Consistent with these various observations, we found that the elevation of SBP induced by cold stress in DS/obese rats was associated with increased systemic glucocorticoid activity, insulin resistance, and cardiovascular inflammation and oxidative stress. Here, FMO5 is linked to Insulin resistance.