In humans, polymorphism in the PLA2G1B gene is a determinant of central obesity.4 In rodent models, both chemical inhibition and genetic inactivation of PLA2G1B are protective against obesity and hyperglycemia in response to chronic feeding of high fat/high carbohydrate diet.5, 6. Here, PLA2G1B is linked to obesity due to melanocortin 4 receptor deficiency.