INS and hyperinsulinism: Consistent with their elevated serum insulin levels, the pancreatic sections of Ks Leprdb/db mice fed a curcumin-supplemented diet contained markedly enlarged islets with numerous Ki-67-positive β-cells (Supplementary Figures 1g–i) similar to those observed in obese Lepob/ob B6 animals with compensatory hyperinsulinemia (Supplementary Figures 1a–c).