Similar to Lepob/ob mice on a C57BL/6 J (B6) background, the Leprdb/db male Ks mice display hyperphagia secondary to a lack of leptin signaling and develop early-onset obesity.65 The addition of curcumin to the diet was associated with an increase in the grams of food consumed in the wild-type B6 mice as well as in the Ks Leprdb/+ heterozygotes (Figure 1). The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.