Similarly, based on a total response rate of 55% in a phase II trial of BTI-322 (antibody directed to CD2 antigen) for steroid-refractory acute GVHD [41], a standard dose of alefacept (15 mg intramuscular) was used for treatment of seven patients in eight acute GVHD episodes of skin, GI and liver with grade 2–4 [25]. This evidence concerns the gene CD2 and acute graft versus host disease.