An association between the SCARB2 gene and PD was hypothesized to be due to differential trafficking of GCase to the lysosome.4 In the current study we hypothesized that if indeed rs6812193 is associated with PD risk via SCARB2, then carriers of the protective nucleotide (T) should have higher GCase activity than carriers of the PD susceptibility allele (C). The gene discussed is SCARB2; the disease is Parkinson disease.