FBXW7 and colorectal carcinoma: Here, we employed the murine intestinal organoid system, to identify cellular response mediated by Fbxw7 to various concentrations of 5-fluorouracil (5-FU), a DNA damage agent commonly administered to metastatic CRC patients.1 We show that fbxw7 gut-specific inactivation (fbxw7ΔG) with high proliferative capacity give rise to microadenoma-like structures.