FBXW7 and neoplasm: Recent excellent reviews on FBXW7 confirm that loss of FBXW7 function is likely to result in failed regulation of its downstream proteins targets, which disrupt a variety of critical signaling pathways resulting in acquisition of the hallmarks of cancer.13–20 Underlining the importance of FBXW7 as a tumor suppressor is the fact that loss of function mutations in the FBXW7 gene occur in a variety of human cancers including 10–15% of CRCs.21–23