To test whether re-expression of FBXW7 render CRC cells sensitive to 5-FU, as Fbxw7α was shown to be the preferentially expressed Fbxw7 isoform in intestine/colon,24 we have overexpressed FBXW7α in both HCT116FBXW7(−/−) and DLD-1FBXW7(−/−) cells. Here, FBXW7 is linked to colorectal carcinoma.