DKK1 and spondyloarthropathy: In addition, both sclerostin and DKK1 have been suggested as biomarkers for disease activity in AS [102], and patients in the German Spondyloarthritis Inception Cohort (GESPIC) were higher risk of developing a syndesmophyte if they had lower levels of circulating functional DKK1 as determined in terms of coating the plate with purified LRP6 but not a capture antibody [103].