Interestingly, an elevated expression of TNF-α, IL-1β, and IL6 was also found in Wnt7b-transfected normal synovial cells; vice versa, an increased level of the inflammatory mediators in turn induced the Wnt/Fzd expression, suggesting a potential involvement of Wnt signaling in the pathobiology of RA [48]. Here, TNF is linked to rheumatoid arthritis.