The lupus nephritis (LN) is an important part of clinical manifestation of SLE; the LN MRL/lpr mice exhibited a phenotype with an enhanced Wnt/β-catenin activity, accompanied by an increased level of DKK1 in the renal tissues and sera and an increased frequency of apoptotic cells of the renal tubular and renal interstitial tissues [106]. Here, DKK1 is linked to systemic lupus erythematosus.