An elevated Wnt signaling activity with increased expression of Wnt signaling components Wnt1, Wnt10b, Fzd2, nuclear β-catenin, and LEF-1 proteins and decreased expression of DKK2 and WIF-1 in skin fibroblasts was observed in SSc patients, which were positively correlated with skin fibrosis [9, 53, 55, 117]. The gene discussed is WIF1; the disease is systemic sclerosis.