After adjustment of age, gender, hypertension, DM, smoking, LDL-C, and HDL-C, multivariate logistic regression analyses resulted in a significant association between NLRP3 rs10754558 and CAD (GG versus CC: AOR = 1.630, 95% CI = 1.080–2.459; CC versus CG + GG: AOR = 1.371, 95% CI = 1.024–1.835; CC + CG versus GG: AOR = 1.392, 95% CI = 0.965–2.007; G allele versus C allele: AOR = 1.263, 95% CI = 1.041–1.534). Here, NLRP3 is linked to coronary artery disorder.