1995a), supporting research indicating attenuated CORT levels shortly after trauma, such as in victims of rape (Resnick et al. 1995) and motor vehicle accidents (Delahanty et al. 2000). Interestingly, similar to observations in PTSD, EE animals exhibited an upregulation of GR mRNA expression in the hippocampus (Mohammed et al. 1993; Olsson et al. 1994), which may serve to facilitate more efficient negative feedback control, thereby blunting the CORT response. Here, NR3C1 is linked to post-traumatic stress disorder.