For example, the 5′ UTR of LCN1 contains cis-sequences associated with the Pax-4, FoxD3, and CP2 transcription factors [28–30]; the Pax-4 transcription factor has been characterized as promoting development and differentiation of the pancreas [31], FoxD3 is a transcriptional repressor [32] and CP2 has been implicated in the regulation of genes associated with allergy pathways [33]. This evidence concerns the gene PAX4 and allergic disease.