CYP7A1 and hydrops fetalis: CYP7A1 was increased by 855 % in the HF + CA group (Fig. 5), and the HF and chow diets showed similar expression levels of CYP7A1. The HF diet significantly elevated both ABCG5 and ABCG8 mRNA expression by 295 and 158 %, respectively (Fig. 5).