The origin of the immunophenotype expression of cyclin D1 is the characteristic translocation of MCL, t(11;14)(q13;q32) that takes place between the IGH gene and the cyclin D1-BCL1 (CCND1) gene, which is considered the primary genetic anomaly of MCL, documented in 70% of MCL cases [9]. This evidence concerns the gene CCND1 and mantle cell lymphoma.