CASP3 and hepatocellular carcinoma: In a previous study, two hepatoma cell lines (SMMC7721 and HepG2) treated with lupeol decreased in a concentration-dependent manner (a) cell viability, (b) the induction of active caspase-3 and poly (ADP-ribose) polymerase cleavage, (c) cell accumulation in the S phase, and (d) apoptosis.